Figure 1.

Hypothesized pathway illustrating a potential methionine and insulin interaction mediated through mTOR. Bi-directional control of methionine and mTORc1 depicts general mechanisms by which methionine is sensed by and activates mTORc1. Insulin also activates mTORc1 by phosphorylating TSC2, and consequently affecting mTORc1 regulation of methionine. Insulin stimulates SREBP mediated lipid synthesis and metabolism. Methionine stimulates SAM PC and PE membrane lipid synthesis. Increased production of reduced glutathione via SAM is thought to reduce the extent of lipid peroxidation.