Table 3.

Relationship between Risk-Factors and Risk of Prevalent Brain Infarcts

	Risk-Ratios of Prevalent Brain Infarcts (RR 95% CI)
Potential Risk-Factor	Overall	Subcortical	Cortical	Cerebellar
Age per 5 years	1.30 (1.19–1.40)	1.43 (1.26–1.63)	1.28 (1.10–1.47)	1.26 (1.13–1.40)
Sex (men vs.women)	1.75 (1.48–2.08)	2.03 (1.49–2.77)	2.55 (1.92–3.37)	1.42 (1.15–1.75)
Hypertension (yes vs no)	2.06 (1.41–3.02)	2.69 (1.06–6.84)	1.42 (0.84–2.42)	2.45 (1.49–4.03)
Systolic BP	1.11 (1.02–1.21)	1.23 (1.06–1.44)	1.05 (0.93–1.19)	1.12 (0.99–1.26)
Diastolic BP	1.03 (0.95–1.12)	1.10 (0.96–1.25)	0.94 (0.83–1.06)	1.07 (0.95–1.19)
Diabetes Mellitus (yes vs no)	1.40 (1.11–1.75)	2.81 (1.92–4.11)	1.31 (0.91–1.89)	1.11 (0.80–1.52)
Smoking (current vs never)	1.26 (0.91–1.74)	1.08 (0.66–1.78)	1.20 (0.76–1.91)	1.33 (0.86–2.06)
Smoking (quit vs never)	1.03 (0.86–1.24)	1.23 (0.86–1.74)	1.01 (0.77–1.33)	1.00 (0.79–1.25)
Atrial Fibrillation	1.44 (1.08–1.91)	0.97 (0.50–1.90)	1.78 (1.17–2.70)	1.39 (0.99–1.96)
Carotid Plaque (≥mod plaque)	1.51 (1.26–1.82)	1.31 (0.92–1.87)	1.81 (1.32–2.49)	1.45 (1.16–1.80)
Migraine (yes vs no)	1.14 (0.90–1.43)	0.96 (0.58–1.60)	1.11 (0.71–1.74)	1.19 (0.92–1.55)
Migraine with aura (yes vs no)	1.50 (1.12–2.02)	1.17 (0.58–2.37)	1.56 (0.84–2.91)	1.56 (1.13–2.15)
Use of lipid lowering medication (yes vs no)	1.63 (1.36–1.95)	1.39 (0.99–1.96)	2.02 (1.53–2.68)	1.52 (1.21–1.91)
Total Cholesterol†	0.97 (0.88–1.08)	0.90 (0.75–1.09)	0.96 (0.81–1.14)	1.04 (0.93–1.15)
High-Density Lipoprotein†	0.95 (0.87–1.04)	0.96 (0.80–1.14)	0.98 (0.83–1.14)	0.94 (0.84–1.06)
Agatston Coronary Calcium	1.31 (1.17–1.46)	1.28 (1.06–1.55)	1.40 (1.16–1.70)	1.27 (1.11–1.46)

For continuous risk factors, the unit of difference was 1 SD, except for age where it was 5 years. All Risk-Ratios are adjusted for age and sex.

^†Additionally adjusted for use of lipid lowering medication.