Table 4.

Relationship between Risk-Factors and Risk of Incident Brain Infarcts

	Risk-Ratios of Incident Brain Infarcts (RR 95% CI)
Potential Risk-Factor	Overall	Subcortical	Cortical	Cerebellar
Age per 5 years	1.45 (1.25–1.70)	1.19 (0.99–1.43)	1.59 (1.28–1.97)	1.45 (1.24–1.69)
Sex (men vs. women)	1.83 (1.49–2.25)	2.27 (1.54–3.33)	2.85 (2.05–3.95)	1.32 (1.03–1.70)
Presence at Baseline (1+ vs 0)	3.06 (2.50–3.75)	5.76 (3.89–8.52)	4.26 (3.00–6.06)	2.96 (2.28–3.86)
Hypertension (yes vs no)	1.93 (1.21–3.07)	1.40 (0.54–3.62)	1.29 (0.61–2.76)	3.27 (1.59–6.74)
Systolic Blood Pressure	1.09 (0.99–1.19)	1.20 (1.03–1.40)	1.02 (0.88–1.19)	1.10 (0.99–1.23)
Diastolic Blood pressure	1.02 (0.90–1.16)	1.29 (1.02–1.64)	0.89 (0.72–1.10)	1.04 (0.91–1.20)
Diabetes Mellitus (yes vs no)	1.21 (0.86–1.71)	1.54 (0.92–2.60)	1.03 (0.61–1.73)	1.25 (0.85–1.82)
Smoking (current vs never)	1.00 (0.71–1.42)	1.00 (0.53–1.88)	0.84 (0.51–1.39)	1.11 (0.70–1.75)
Smoking (quit vs never)	0.96 (0.76–1.21)	0.94 (0.61–1.45)	0.90 (0.62–1.29)	1.01 (0.76–1.34)
Atrial Fibrillation	1.09 (0.73–1.64)	0.64 (0.27–1.51)	1.31 (0.68–2.52)	1.07 (0.68–1.69)
Carotid Plaque (≥mod plaque)	1.27 (1.01–1.59)	1.03 (0.68–1.57)	1.93 (1.29–2.89)	1.07 (0.81–1.40)
Migraine (yes vs no)	1.24 (0.94–1.63)	0.79 (0.40–1.58)	1.16 (0.72–1.88)	1.40 (1.00–1.96)
Migraine with aura (yes vs no)	1.44 (0.96–2.16)	1.19 (0.51–2.82)	1.78 (0.98–3.24)	1.33 (0.79–2.24)
Use of lipid lowering medication (yes vs no)	1.03 (0.81–1.31)	0.92 (0.61–1.40)	1.28 (0.89–1.84)	0.92 (0.69–1.22)
Total Cholesterol†	0.95 (0.80–1.12)	0.89 (0.69–1.16)	1.09 (0.85–1.40)	0.89 (0.75–1.06)
High-Density Lipoprotein†	0.94 (0.82–1.08)	0.99 (0.79–1.23)	0.93 (0.75–1.14)	0.93 (0.80–1.09)
Agatston Coronary Calcium	1.19 (1.06–1.33)	1.05 (0.83–1.32)	1.29 (1.05–1.59)	1.18 (1.03–1.35)

For continuous risk-factors, the unit of difference was 1SD, except for age where it was 5 years. All Risk-Ratios are adjusted for age, sex and time interval between MR scans.

^†Additionally adjusted for use of lipid lowering medication