Table 4.
Settings for non-proportional subdistribution hazards data generation
| Setting 5 | Setting 6 | Setting 7 | Setting 8 | |
|---|---|---|---|---|
| Main effect of Z on AF | Yes | Yes | Yes | No |
| Time-varying effect of Z on AF | Yes | Yes | Yes | Yes |
| Main effect of Z on death | Yes | Yes | Yes | Yes |
| Subdistribution HR for AF | 1.649e−1.72t | 1.649e−2.2t | 1.6487e0.5t | e 0.5t |
| Gompertz parameters | ||||
| γ | 1.2 | 1.2 | 1 | 1 |
| ρ | −2 | −2 | −3 | −3 |
| Effect of Z on AF, ψ1 | 0.5 | 0.5 | 0.5 | 0 |
| Time-varying effect of Z on AF, ψ2 | −1.72 | −2.2 | 0.5 | 1 |
| Effect of Z on death, ψ3 | 0.5 | 0.5 | 0.5 | 0.5 |
| Lifetime risk, Z=1 | 0.40 | 0.37 | 0.45 | 0.35 |
| Lifetime risk, Z=0 | 0.40 | 0.40 | 0.27 | 0.27 |
| Difference in lifetime risk | 0.00 | −0.03 | 0.18 | 0.08 |
AF: atrial fibrillation, HR: cause-specific hazard ratio. Sample size before left truncation was set to n=500 and n=1,000. Right censoring was generated from a Uniform(c,d) distribution, where parameters c and d were set to obtain 25% and 75% probability of censoring at τ. Left truncation times were generated from a Uniform(0,5) distribution for 50% and 80% of individuals.