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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: J Control Release. 2022 Jan 22;343:142–151. doi: 10.1016/j.jconrel.2022.01.023

Figure 3: Synthesis and in vitro hydrolysis of TRAP paclitaxel.

Figure 3:

A) Paclitaxel (1 eq.), succinic anhydride (2 eq.) and DMAP (1 eq.) reacted in anhydrous DCM to get paclitaxel succinic acid. Purified paclitaxel succinic acid (1 eq.), EDC (1 eq.) and sNHS (1 eq.) reacted in anhydrous DCM to get paclitaxel sNHS (TRAP paclitaxel). B) Kinetics of paclitaxel succinate hydrolysis at pH 6.5 and 7.4 (solid lines) and release of free paclitaxel (dashed lines) over time.