Fig. 1. Occupancy and dose relationship for antidepressants administered at four or more doses.

The dose-occupancy relationship for antidepressants that were administered at four or more different doses (citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, paroxetine, venlafaxine, and vortioxetine), fitted according to a 2-parameter Michaelis–Menten model as $f\left(x,K,V_m\right)=\frac{V_{m}x}{K+x}$, where V_m is the horizontal asymptote (expressing maximum occupancy), x is the drug dose and the parameter K is the dose where the occupancy is halfway between 0 and V_m. The parameter estimates V_m and K for each model are provided in Supplementary Table 2. For each individual figure, studies are represented by uniquely colored dots; the size of the dots is proportional to the number of occupancy measures. Dashed vertical lines represent the usual minimum recommended dose.