Table 3.
Top findings on GWAS performed on cocaine use disorders.
| rs ID | P value | Gene | Childhood environmental factors | Association | Sample | SNP heritability | Ref. |
|---|---|---|---|---|---|---|---|
| rs2629540 | 4.28E−08* | FAM53B | – | Dependence (DSM-IV) |
2668 AA, 2101 EA |
0.28 | [39] |
| rs150954431 | 1.19E−09 | NCOR2 | |||||
| rs3075660 | 3.83E−07 | NRG3 | – | Dependence (DSM-IV) | 6378 EA | 0.27–0.30 | [44] |
| rs10188036 | 1.77E−08 | TRAK2 | Change in residence | Dependence (DSM-5) | 2998 AA | – | [6] |
| del-13:61274071 | 4.94E−08 | LINC00378 | Household drinking and illicit drug use | ||||
| del-1:15511771 | 3.61E−10 | TMEM51 | Nontraditional parental care | Subtype 5a | 1916 | ||
| rs149843442 | 3.92E−08 | LPHN2 | Household tobacco use | ||||
| rs114492924 | 1.23E-08 | LINC01411 | Change in residence | ||||
| rs139389287 | 3.51E−08 | RP13–20L14.1 | Household tobacco use | ||||
| rs148834561 | 4.71E−08 | SLC7A13 | Household drinking and illicit drug use | ||||
| del-17:80342628 | 1.54E−08 | TRDN | Change in residence | ||||
| rs75591854 | 3.91E−08 | SOGA2 | Household tobacco use/Change in residence | ||||
| rs75414569 | 9.73E−09 | RN7SL609P | Household tobacco use | ||||
| rs148009780 | 4.74E−08 | SYNGR1 | Change in residence | ||||
| rs71428385 | 3.99E−08 | FN1 | Household tobacco use | Subtype 4a | 3258 | ||
| rs56337958 | 3.07E−08 | TENM3 | Traumatic experience | ||||
|
rs61835088 rs2825295 |
3.79E−09 2.57E−08 |
FAM78B AL157359.3-AP000431.1 |
– | Time to dependence (DSM-IV) | 11,026 AA+EA 5020 AA | – | [47] |
EA European–Americans, AA African–Americans.
*P value results from the combination of other replica samples used in the study.
aSubtypes 4 and 5 of cocaine use disorders resulting from cluster analysis.