Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 6;38(2):205–224. doi: 10.1007/s43188-021-00103-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 10 — Sex-specific dysregulation of Wnt pathway and epigenetic chromatin modification genes in mice exposed in utero to e-cig aerosols at PND11. In male offspring, a total of 20 genes were dysregulated at this time point and 2 genes were in common with the female offspring. The 18 male-only dysregulated genes included the up-regulation of 13 genes from Wnt signaling and 2 genes associated with epigenetics (Ncoa3 and Suv39h1), in addition to the down-regulation of 1 gene related to Wnt (Sfrp2) and 2 genes linked to epigenetic modifications. In the female offspring, the 25 female-only dysregulated genes included the up-regulation of 7 genes from Wnt signaling and 2 genes associated with epigenetics (Prmt2 and Kat6b), in addition to the down-regulation of 1 gene related to Wnt (Fgf4) and 15 genes linked to epigenetic modifications