Table 1.

Antibiotics used for the treatment of CRAB infections

Agent	Adult dosage (assuming normal renal and liver function)	Remarks	Major toxicities to consider
aAmpicillin-sulbactam	3 g every 4 h if intolerance or toxicities preclude the use of higher dosages or for mild infections		Hepatotoxicity (1%)
aAmpicillin-Sulbactam	9 g every 8 h, each dose given over 4 h 27-g continuous infusion over 24 h	High dose, suitable for ampicillin-sulbactam-resistant CRAB
Cefiderocol	2 g every 8 h infused over 3 h		Elevated liver tests (2–16%) Hypokalemia (11%)
Colistin	As per international consensus guidelinesb		Nephrotoxicity (1–18%) Neurotoxicity (1–7%)
Eravacycline	1 mg/kg/dose every 12 h		GI (2–7%)
cImipenem-cilastatin	500 mg every 6 h infused over 3 h		Seizures (1%)
cMeropenem	2 g every 8 h infused over 3 h		Seizures (< 1%)
Minocycline	200 mg every 12 h		CNS (1–3%)
Tigecycline	200 mg once, then 100 mg every 12 h	High dose	Hepatotoxicity (2–5%) Pancreatitis (< 1%),

CRAB carbapenem-resistant Acinetobacter baumannii

^aCurrently only ampicillin-sulbactam is considered appropriate for monotherapy; all other drugs should be used based on susceptibly as a combination with ampicillin sulbactam except in penicillin-allergic patients

^bTsuji BT, Pogue JM, Zavascki AP, et al. International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti-infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP). Pharmacotherapy 2019; 39(1): 10–39

^cCarbapenems may be considered as a third drug in combination regiments