Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
MRI characteristics associated with TITF-1, ADCY5, and PDE10A mutations.
| Gene | Gene product | Inheritance | Age of onset | MRI characteristic features |
|---|---|---|---|---|
| TITF-1/NKX2-1 | Thyroid transcription factor 1 | AD/de novo | Childhood/adulthood | Altered sella turcica morphology |
| ADCY5 | Adenylate cyclase 5 | AD/de novo | Infancy to childhood | Frontoparietal cortex and thalamus atrophy |
| PDE10A | Phosphodiesterase 10A | De novo/AD/AR | Infancy to childhood | Bilateral striatal hyperintensities and bilateral striatal atrophy |
