Table 2.
Heart disease SMRs by calendar year of diagnosis and treatment type
| Overall (N = 516,916) | Surgery only (n = 197,449) | Chemotherapy alone (n = 76,479) | Chemotherapy plus radiotherapy (n = 102,838) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| O | SMR | 95% CI | O | SMR | 95% CI | O | SMR | 95% CI | O | SMR | 95% CI | |
| Calendar year of diagnosis | ||||||||||||
| 1975–1979 | 6586 | 1.01 | (0.98, 1.03) | 5007 | 0.92 | (0.90, 0.95) | 257 | 0.88 | (0.77, 0.99) | 132 | 1.71 | (1.43, 2.02) |
| 1980–1984 | 6844 | 1.00 | (0.98, 1.02) | 5083 | 0.96 | (0.93, 0.98) | 457 | 0.94 | (0.86, 1.03) | 170 | 1.34 | (1.15, 1.56) |
| 1985–1989 | 7799 | 0.90 | (0.88, 0.92) | 5669 | 0.91 | (0.88, 0.93) | 354 | 0.91 | (0.82, 1.01) | 181 | 1.02 | (0.88, 1.18) |
| 1990–1994 | 7116 | 0.89 | (0.87, 0.91) | 4494 | 0.95 | (0.92, 0.97) | 421 | 0.93 | (0.85, 1.03) | 267 | 0.82 | (0.72, 0.92) |
| 1995–1999 | 5866 | 0.87 | (0.85, 0.89) | 2930 | 0.96 | (0.93, 1.00) | 382 | 0.98 | (0.88, 1.08) | 440 | 0.80 | (0.73, 0.88) |
| 2000–2004 | 3793 | 0.82 | (0.80, 0.85) | 1635 | 0.94 | (0.89, 0.99) | 313 | 0.95 | (0.85, 1.06) | 445 | 0.77 | (0.70, 0.85) |
| 2005–2009 | 1988 | 0.80 | (0.76, 0.83) | 829 | 0.95 | (0.89, 1.02) | 202 | 1.01 | (0.87, 1.16) | 277 | 0.83 | (0.73, 0.93) |
| 2010–2016 | 820 | 0.74 | (0.69, 0.79) | 326 | 0.89 | (0.79, 0.99) | 89 | 1.01 | (0.81, 1.25) | 127 | 0.76 | (0.63, 0.90) |
| Coefficient, ptrend | (− 0.009), p < 0.001 | (+ 0.0003), p = 0.66 | (+ 0.003), p = 0.11 | (− 0.021), p < 0.001 | ||||||||
| Radiotherapy alone (n = 140,150) | Left-sided radiotherapya (n = 70,761) | Right-sided radiotherapya (n = 69,119) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| O | SMR | 95% CI | O | SMR | 95% CI | O | SMR | 95% CI | |
| Calendar year of diagnosis | |||||||||
| 1975–1979 | 1190 | 1.58 | (1.49, 1.67) | 672 | 1.77 | (1.64, 1.91) | 511 | 1.39 | (1.27, 1.51) |
| 1980–1984 | 1134 | 1.23 | (1.16, 1.30) | 650 | 1.37 | (1.27, 1.48) | 482 | 1.08 | (0.99, 1.18) |
| 1985–1989 | 1595 | 0.88 | (0.84, 0.93) | 841 | 0.93 | (0.87, 0.99) | 750 | 0.84 | (0.78, 0.90) |
| 1990–1994 | 1934 | 0.79 | (0.75, 0.82) | 973 | 0.78 | (0.73, 0.83) | 959 | 0.80 | (0.75, 0.85) |
| 1995–1999 | 2114 | 0.77 | (0.73, 0.80) | 1037 | 0.75 | (0.70, 0.79) | 1074 | 0.78 | (0.74, 0.83) |
| 2000–2004 | 1400 | 0.71 | (0.67, 0.75) | 709 | 0.72 | (0.67, 0.77) | 690 | 0.70 | (0.65, 0.76) |
| 2005–2009 | 680 | 0.63 | (0.58, 0.67) | 322 | 0.57 | (0.51, 0.64) | 357 | 0.68 | (0.61, 0.75) |
| 2010–2016 | 278 | 0.57 | (0.50, 0.64) | 142 | 0.57 | (0.48, 0.68) | 136 | 0.56 | (0.47, 0.67) |
| Coefficient, ptrend | (− 0.028), p < 0.001 | (− 0.032), p < 0.001 | (− 0.02), p < 0.001 | ||||||
O observed heart disease events, SMR standardized mortality ratio, CI Confidence interval
aRestricted to women with unilateral disease and known laterality