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. 2022 Feb 2;192(3):611–622. doi: 10.1007/s10549-022-06515-5

Table 2.

Heart disease SMRs by calendar year of diagnosis and treatment type

Overall (N = 516,916) Surgery only (n = 197,449) Chemotherapy alone (n = 76,479) Chemotherapy plus radiotherapy (n = 102,838)
O SMR 95% CI O SMR 95% CI O SMR 95% CI O SMR 95% CI
Calendar year of diagnosis
 1975–1979 6586 1.01 (0.98, 1.03) 5007 0.92 (0.90, 0.95) 257 0.88 (0.77, 0.99) 132 1.71 (1.43, 2.02)
 1980–1984 6844 1.00 (0.98, 1.02) 5083 0.96 (0.93, 0.98) 457 0.94 (0.86, 1.03) 170 1.34 (1.15, 1.56)
 1985–1989 7799 0.90 (0.88, 0.92) 5669 0.91 (0.88, 0.93) 354 0.91 (0.82, 1.01) 181 1.02 (0.88, 1.18)
 1990–1994 7116 0.89 (0.87, 0.91) 4494 0.95 (0.92, 0.97) 421 0.93 (0.85, 1.03) 267 0.82 (0.72, 0.92)
 1995–1999 5866 0.87 (0.85, 0.89) 2930 0.96 (0.93, 1.00) 382 0.98 (0.88, 1.08) 440 0.80 (0.73, 0.88)
 2000–2004 3793 0.82 (0.80, 0.85) 1635 0.94 (0.89, 0.99) 313 0.95 (0.85, 1.06) 445 0.77 (0.70, 0.85)
 2005–2009 1988 0.80 (0.76, 0.83) 829 0.95 (0.89, 1.02) 202 1.01 (0.87, 1.16) 277 0.83 (0.73, 0.93)
 2010–2016 820 0.74 (0.69, 0.79) 326 0.89 (0.79, 0.99) 89 1.01 (0.81, 1.25) 127 0.76 (0.63, 0.90)
Coefficient, ptrend (− 0.009), p < 0.001 (+ 0.0003), p = 0.66 (+ 0.003), p = 0.11 (− 0.021), p < 0.001
Radiotherapy alone (n = 140,150) Left-sided radiotherapya (n = 70,761) Right-sided radiotherapya (n = 69,119)
O SMR 95% CI O SMR 95% CI O SMR 95% CI
Calendar year of diagnosis
 1975–1979 1190 1.58 (1.49, 1.67) 672 1.77 (1.64, 1.91) 511 1.39 (1.27, 1.51)
 1980–1984 1134 1.23 (1.16, 1.30) 650 1.37 (1.27, 1.48) 482 1.08 (0.99, 1.18)
 1985–1989 1595 0.88 (0.84, 0.93) 841 0.93 (0.87, 0.99) 750 0.84 (0.78, 0.90)
 1990–1994 1934 0.79 (0.75, 0.82) 973 0.78 (0.73, 0.83) 959 0.80 (0.75, 0.85)
 1995–1999 2114 0.77 (0.73, 0.80) 1037 0.75 (0.70, 0.79) 1074 0.78 (0.74, 0.83)
 2000–2004 1400 0.71 (0.67, 0.75) 709 0.72 (0.67, 0.77) 690 0.70 (0.65, 0.76)
 2005–2009 680 0.63 (0.58, 0.67) 322 0.57 (0.51, 0.64) 357 0.68 (0.61, 0.75)
 2010–2016 278 0.57 (0.50, 0.64) 142 0.57 (0.48, 0.68) 136 0.56 (0.47, 0.67)
Coefficient, ptrend (− 0.028), p < 0.001 (− 0.032), p < 0.001 (− 0.02), p < 0.001

O observed heart disease events, SMR standardized mortality ratio, CI Confidence interval

aRestricted to women with unilateral disease and known laterality