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. 2022 Feb 26;297(2):591–600. doi: 10.1007/s00438-022-01869-3

Table 1.

Demographic and clinical descriptions of NSCLC patients in the discovery and validation phases

Variable Discovery phase (N = 604) Validation phase (N = 839)
Age (years) 66.02 ± 9.55 63.51 ± 9.34
Gender, N (%)
 Male 355 (58.77%) 411 (56.38%)
 Female 249 (41.23%) 318 (43.62%)
 Unknown 0 110
Race, N (%)
 Asian 8 (1.32%) 0
 Black 55 (9.11%) 0
 White 541 (89.57%) 0
 Unknown 0 839
Smoke status, N (%)
 Never 0 26 (6%)
 Former 416 (68.87%) 243 (56.12%)
 Current 188 (31.13%) 164 (37.88%)
 Unknown 0 406
Smoking packs every year 47.38 ± 29.96
Clinical stage, N (%)
 I 328 (54.30%) 496 (68.04%)
 II 171 (28.31%) 172 (23.59%)
 III 88 (14.57%) 53 (7.27%)
 IV 17 (2.81%) 8 (1.10%)
 Unknown 0 110
Histology, N (%)
 LUAD 294 (48.68%) 634 (75.57%)
 LUSC 310 (51.32%) 205 (24.43%)
Survival year
 Median (95% CI) 3.91 (3.33–4.93) 7.53 (6.30–8.92)
 Censoring rate 59.60% 55.66%

The validation phase consists of six datasets from GEO, including GSE3141 (N = 110), GSE37745 (N = 172), GSE30219 (N = 104), GSE50081 (N = 172), GSE31210 (N = 226) and GSE29013 (N = 55)