Table 1.

HAS 1–3 gene expression pattern during murine embryonic development. (“Plus” signs indicate relative concentration of each molecule.) All three Has synthases are present in the indicated organs at various timepoints throughout embryo development. Major takeaways include the highest expression of all three Has synthases in the heart at E9, with skin showing the highest expression relative to other organs from E11 to at least E17. At E17, HAS1–3 are observed in the kidney and vitreous body for the first time

	E9 (embryonic stage)			E11-13		E15		E17
	Neural tube	Lung	Heart	Dermis	Mesenchyme	Epidermis	Cartilage	Epidermis	Bone	Kidney	Vitreous body
Has1	++	++	+++	+++	++	++	++	++		++	+
Has2	+++	+++	+++	+++	+	++	+++	+++	++	++	+
Has3	+	+	+++	+++	++	++	++	+++	++	++	+