FIGURE 5.
Identification of differentially expressed mitochondrial proteins. (A) The distribution of p-values (−log10) and z-scores (log2) in 1,313 quantified mitochondrial proteins between the htau and WT mice. A total of 65 (5 months, synaptic), 47 (8 months, synaptic), 38 (5 months, non-synaptic), and 49 (8 months, non-synaptic) proteins were selected as differentially expressed, which exhibited a p-value < 0.05 and a z-score > 1 standard deviation (highlighted in red). (B) Quantification of relative expression of indicated differentially expressed proteins as determined by SWATH-MS analysis. Differential expression (p-value < 0.05 and z-score > 1 standard deviation (annotated by a*).