TABLE 1.
Enrichment of GO biological process terms for differentially expressed proteins in htau mice.
| Mitochondrial pool | Biological process term | % | p-Value | Genes |
| 5 months, synaptic | oxidation-reduction process | 15.4 | 2.80E-04 | Bdh1, ND5, Acadm, Akr7a5, Aifm1, Chchd4, Ethe1, Gpd1, Moab, Ptgs1 |
| apoptotic process | 10.8 | 9.70E-03 | Dnaja3, Aifm1, Fam162a, Fis1, Mapt, Sgpl1, Trpv2 | |
| 8 months, synaptic | microtubule-based process | 6.4 | 4.50E-03 | Tuba4a, Tubb3, Tubb4a |
| 5 months, non-synaptic | oxidation-reduction process | 15.8 | 1.00E-02 | Ndufb8, Cat, Dhrs4, Hsd17b12, Mthfd1, Pcyox1 |
| translation | 13.2 | 8.00E-03 | Eif4gl, Mrpl17, Mrpl55, Rpl12, Slc25a51 | |
| 8 months, non-synaptic | transport | 22.4 | 1.10E-02 | Atp5e, Atp1b3, Cadps, Etfb, Eif5a, Gosr2, Lrpprc, Mtx2, Nup155, Slc6a6, Vps45 |
| protein transport | 12.2 | 1.40E-02 | Cadps, Eif5a, Gosr2, Mtx2, Nup155, Vps45 |
Differentially expressed proteins in mitochondria isolated from htau mice were analyzed using DAVID to identify biological processes affected by human tau expression.