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. 2022 Mar 10;13:812535. doi: 10.3389/fphys.2022.812535

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Copyright © 2022 Peris-Yagüe, Rubio, Fakuade, Voigt, Luther and Majumder.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spiral wave breakup in a 2D pig atrial tissue of size 11.26 × 11.26 cm² with G_{Kr, max} reduced to 0.25x its value in the healthy pig model. (A) Pseudocolour plots of the membrane voltage distribution at different times demonstrates the occurrence of multiple spiral waves in the domain. (B) Quantification of number of spiral waves in the domain at various times, measured as the number of phase singularities (one located at each spiral tip).