Table 2.
The results of drug resistance gene examination of hepatitis B virus (HBV; July 2019).
| Drug | Genetic locus | Potential phenotype | Comprehensive phenotype | |||
|---|---|---|---|---|---|---|
| lamivudine (LAM) | major: rtM204I | rtM204V | rtM204S | S | U | |
| minor: rtL80I | rtL80V | rtV173L | S | |||
| rtL180M | rtA181T | rtA181V | ||||
| undetermined: rtV207I | rtV207L | rtV207M | U | |||
| rtS213T | rtL229F | rtL229G | ||||
| rtL229M | rtL229V | rtL229W | S | |||
| tibivudine (LdT) | major: rtM204I | rtM204V | rtM204S | S | ||
| minor: rtV173L | rtL180M | S | ||||
| emtricitabine (FTC) | major: rtM204I | rtM204V | rtM204S | S | S | |
| minor: rtV173L | rtL180M | S | ||||
| adefovir (ADV) | major: rtA181S | rtA181T | rtA181V | S | S | |
| rtN236T | rtN236V | |||||
| undetermined: rtV84M | rtS85A | rtS85T | S | |||
| rtV214A | rtQ215H | rtQ215P | ||||
| rtQ215S | rtI233V | rtP237H | ||||
| rtN/H238D | rtN/H238S | rtN/H238T | ||||
| tenofovir (TDF) | major: rtA194T | rtA194M | S | S | ||
| minor: rtN236T | rtN236V | S | ||||
| entecavir (ETV) | major: rtT184A | rtT184C | rtT184F | S | S | |
| rtT184G | rtT184I | rtT184L | ||||
| rtT184M | rtT184S | rtS202C | ||||
| rtS202G | rtS202I | rtM250I | ||||
| rtM250L | rtM250V | S | ||||
| minor: rtI169T | rtV173L | rtL180M | ||||
| rtM204I | rtM204V | rtM204S | ||||