Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 28;5:277. doi: 10.1038/s42003-022-03224-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a Scatter plot of nascent pre-mRNA level changes (log₂FC) versus GSI changes (∆GSI) after 2 h of TGFβ treatment. Genes with decreased GSI (∆GSI < –0.5, p < 0.05) or increased GSI (∆GSI > 0.5, p < 0.05) are depicted in red or blue, respectively. b Boxplot of nascent pre-mRNA level changes (log₂FC) after 2 h of TGFβ treatment versus vehicle, for genes with decreased or increased GSI values. Unpaired Student’s t-test p-values are shown. c, d GSI levels at the three conditions tested (vehicle, 2 and 12 h of TGFβ treatment) for genes with decreased GSI (c) or increased GSI (d) after 2 h of TGFβ treatment. e ChrRNA-seq and RNA-seq IGV snapshot of Ncam1 gene as example of a transient change of GSI after 2 h of TGFβ. f, g Changes of mature mRNAs level (log₂FC) after 2 h or 12 h of TGFβ of genes with decreased (f) or increased GSI (g) at the 2 h TGFβ time point. c, d, f, g Paired Student’s t-test p-values of the comparison between the indicated distributions are shown. Sample size (n) of all set of data are provided in Supplementary Data 4.