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. 2022 Mar 28;8:134. doi: 10.1038/s41420-022-00945-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A LDH activity assay showed that 100 mM alcohol can induce the upregulation of LDH expression in hiPSC-CMs 2.5 times (n = 7). B HTS analysis showed that the red-green fluorescence ratio has significantly dropped (n = 7). C The representative immunofluorescence image of JC-1 labeling showed that the green fluorescence expression of hiPSC-CMs significantly increased after treatment with 100-mM alcohol for 2 h. Scale bar = 25 μm. D, E Flow cytometry and quantitative analysis showed that 100-mM alcohol increased early apoptosis of hiPSC-CMs (n = 3). Results are presented as means ± standard error of the mean (**P < 0.01; two-sided Student’s t-test or one-way analysis of variance).