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. 2022 Mar 28;5:275. doi: 10.1038/s42003-022-03226-x

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Fig. 1 — a The metal-binding members of the ArsR-SmtB class act as repressors of the target gene in the apo-state. In contrast, when bound to a metal ion, a conformational change ensues, and transcription of the target gene is initiated^23,24. b RexT is a non-canonical member of the ArsR-SmtB family of transcriptional regulators. Rather than binding metal ions, RexT is proposed to respond to H₂O₂ stress through formation of a disulfide bond that initiates transcription of the thioredoxin-encoding gene trxA2¹⁷.