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. 2022 Mar 26;13(3):271. doi: 10.1038/s41419-022-04708-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A HE staining showed that MSC-Exo treatment alleviated CCl₄-induced ALI. B MSC-Exo dramatically reversed the increased serum levels of ALT and AST induced by CCl₄. C UPLC-MS/MS detection indicated significant upregulation of the serum MDA level induced by CCl₄, which was downregulated following MSC-Exo treatment. D MSC-Exo treatment significantly reversed the increased mRNA levels of Ptgs2, 15-LOX, 12-LOX, and 5-LOX induced by CCl₄ in the liver. E WB analysis of CD63 and CD81 in exosomes extracted from MSC-conditioned medium and GW4869 pretreated MSC-conditioned medium. F Lipid peroxidation was measured using C11-BODIPY^581/591 staining in L-02 cells treated with CCl₄, CCl₄ + Medium, CCl₄ + MSC, CCl₄ + MSC (pretreated with GW4869), and CCl₄ + Fer-1 (left panel). After replacing CCl₄ with erastin, the above experiment was repeated three times (right panel). G Representative histograms of C11-BODIPY^581/591 staining. Significance was calculated by one-way ANOVA with Tukey’s post hoc test. *p < 0.05 or **p < 0.001 indicated a significant difference between groups.