Table 2.

Plasma metabolites differentiating RHD patients from control group.

	VIP	P value	Log2(FC)	FDR	AUC
Caprolactam	2.3412	3.31E−24	−1.2333	1.16E−21	0.967
N-Acetylneuraminate	2.1912	1.27E−05	2.0395	0.000149	0.824
Trans-4-hydroxy-l-proline	2.0438	8.19E−07	−1.6103	2.05E−05	0.779
Dihydroxymandelic acid	2.04	4.05E−06	−2.3744	5.92E−05	0.736
Arachidonic acid	1.8545	2.82E−08	1.4512	1.24E−06	0.805
d-Sphingosine	1.7667	1.99E−05	0.88739	0.000208	0.768
16(R)-HETE	1.7518	2.40E−06	0.71539	4.44E−05	0.733
Orotate	1.7127	0.00309	1.3078	0.013226	0.58
Inosine	1.6591	0.001455	2.44	0.006809	0.719
Hypoxanthine	1.6467	0.005737	1.3465	0.022375	0.747
Linoleate	1.595	0.006022	2.1162	0.023227	0.76
Prostaglandin B1	1.5482	5.03E−06	1.1173	6.61E−05	0.758
d-( +)-pyroglutamic acid	1.4993	3.12E−06	0.8164	5.01E−05	0.773
Alpha-aspartylphenylalanine	1.4817	0.016667	−1.7362	0.047952	0.667
l-5-Hydroxytryptophan	1.4711	3.33E−10	0.70395	3.89E−08	0.876
Adenosine monophosphate	1.4458	0.000781	0.80453	0.004153	0.721
l-Glutamic acid	1.4397	3.27E−06	0.75709	5.01E−05	0.751
5-Methoxysalicylic acid	1.4297	5.09E−06	0.9186	6.61E−05	0.747
Prostaglandin A1	1.4266	6.22E−05	1.1885	0.000555	0.71
2'-Deoxyuridine	1.3609	0.000346	−1.1365	0.002131	0.692
d-Pantothenic acid	1.3421	0.001059	0.83355	0.005236	0.808
Alpha-lactose	1.2985	8.95E−05	−0.73137	0.000748	0.742
Xanthine	1.2797	0.000363	1.3465	0.002158	0.731
4-Nitrophenol	1.2617	9.41E−08	−0.65097	3.30E−06	0.803
4-Anisic acid	1.2602	0.00021	−1.4004	0.001502	0.717

VIP score variable of importance score obtained from PLS-DA analysis (VIP > 1.2), p value p value of the Wilcoxon signed-rank test, Log2(FC) log2 value of fold change, FC fold change (FC > 1.5), FDR false discovery rate, AUC area under the curve calculated from ROC analysis.