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. 2022 Mar 28;12:125. doi: 10.1038/s41398-022-01848-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Example cortex Western blot. b E2 mice had the lowest GR/APOE ratio (+p < 0.05) and E3 and E4 CVS-exposed mice showed larger ratios compared to controls (#p < 0.05). c LDLR/apoE ratios had similar differences to the GR/apoE ratios (+p < 0.05, #p < 0.05). d Example adrenal gland Western blot. e E2 mice had the highest apoE levels in adrenal glands (+p < 0.05). f GR in the adrenal gland was higher in CVS-exposed mice (*p < 0.05). g GR/apoE ratios were lowest in E2 mice (+p < 0.05). CVS-exposure resulted in higher GR/apoE ratio compared to controls (*p < 0.05). h E2 mice had the lowest LDLR/apoE ratios (+p < 0.05). i Plasma levels of apoE were highest in E2 mice (+p < 0.05). Furthermore, E2 mice exposed to CVS had lower apoE levels compared to controls (*p < 0.05). Female E2 mice had more plasma apoE than male E2 mice (⁰p < 0.05). j In cortical tissue, CVS exposure led to lower apoE levels (*p < 0.05). k Meanwhile, MAP-2 levels in the cortex were higher in mice exposed to CVS (*p < 0.05). l Female cortical tissue showed a genotype x group interaction in which only E4 mice exposed to CVS showed higher levels of 7-ketocholesterol compared to controls (#p < 0.05). m CVS exposure was associated with higher 7-ketocholesterol levels (*p < 0.05) regardless of genotype or sex (shown collapsed). n Plasma levels were highest in E2 mice (+p < 0.05, shown with sexes collapsed). Symbols: + refers to pairwise comparison of genotype effect, * refers to CVS effect, ^ refers to sex effect, # refers to genotype x CVS interaction, 0 refers to sex x genotype interaction.