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. 2022 Mar 28;12:5259. doi: 10.1038/s41598-022-08972-w

Table 3.

Summary of the developmental process of the sphenoid during the embryonic period.

CS Summary
17 The orbitosphenoid (OS) appears first, followed by the basisphenoid (BS)
18

OS and BS have stronger cellular condensation

The presphenoid (PS) and alar process (AP) develop from the anterior and the back lateral of BS, respectively

Mesenchymal cells around the maxillary nerve begin to proliferate (ala temporalis [AT] condensation)

19

An unclear condensation of the mesethmoid (ME) appears in front of PS

The foramen rotundum (FR) begins to develop as a bottom half-completed hole within AT

Cartilaginous matrix and perichondrium are little formed at this stage

Almost all elements still do not have connections with each other

20

OS bends and begins to wrap around the optic nerve to form the optic canal

PS fuses in the middle and continues to ME

OS and BS have cartilaginous matrix and perichondrium

Most elements connect with each other

21

In a few specimens, the medial pterygoid process (MP) develops from the inferomedial of AT

FR completes its entire hole

ME extends longer toward anterior by connecting with the nasal septum

All elements fuse each other, and the boundaries between them become invisible

22, 23

OS enlarges and bends along the optic nerve, and the optic canal is almost fully encircled

The lateral part of the lesser wing appears as an unclear and sharp condensation outward from OS in some specimens

MP extends longer toward the oral cavity

Most elements have massive matrices and clear perichondrium