TABLE 2.

Lamivudine final model parameter estimates

Parameter	Population estimate	95% CIa	% CV	SE (θ)b	ηc	SE (η)
CL/F (liters/h),d θ1	25.1	23.8–26.4	35.2	0.683	0.124	0.0183
V/F (liters),e θ2	128	117–139	31.1	5.72	0.0965	0.0278
ka (h−1),f θ3	4.65	2.18–7.12		1.26
θ4	0.468	0.233–0.703		0.120

^aCI, confidence interval. 

^bθ, fixed effects. 

^cη, random effects between individuals. 

^dIf male, CL/F = [θ₁ · (140 − age/serum creatinine · 100)^θ₄ EXP_η2] · weight/70; if female, CL/F = {θ₁ · [(140 − age/serum creatinine · 100) · 0.85]^θ₄ · Exp_η2} · weight/70. 

^eV/F = θ₂ · EXP_η2. 

^fka = θ₃. Error model: F · EXP(ɛ₁).