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ShERPA derivatives in the receptor active site. Close view representations of ERα-E2 (yellow) superimposed with (A) TTC-352 (blue) and (B) BMI-135 (cyan). Snapshots extracted from the MD trajectories are depicted for each receptor-ligand complex. The key interactions in the active site are shown (in dash lines) together with the positioning of helix12 in comparison with the ERα-E2 structure.
