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. 2022 Mar 10;12:842356. doi: 10.3389/fonc.2022.842356

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Copyright © 2022 Yao, Guo, Zhang, Chen, Xu, Luo, Luo, Lin, Chen, Li and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of LDHA attenuates glycolysis and suppresses tumor proliferation in ABC-DLBCL. (A) QRT-PCR analysis of LDHA mRNA expression in SU-DHL-2 and OCI-LY-10 cell lines. LDHA expression was detected after transfecting with siRNA of LDHA. Experiments were performed in triplicate, and data are presented as the mean ± SD. ***P < 0.001; one-way ANOVA. (B) downregulation of LDHA inhibits intracellular LDH in SU-DHL-2 and OCI-LY-10 cells. Experiments were performed in triplicate, and data are presented as the mean ± SD. **P < 0.01; and ***P < 0.001; one-way ANOVA. (C) inhibition of LDHA reduced intracellular lactate production in SU-DHL-2 and OCI-LY-10 cells. Experiments were performed in triplicate, and data are presented as the mean ± SD. **P < 0.01; one-way ANOVA. (D) inhibition of LDHA reduced ATP production in SU-DHL-2 and OCI-LY-10 cells. Experiments were performed in triplicate, and data are presented as the mean ± SD. *P < 0.05; and **P < 0.01; one-way ANOVA. (E, F) CCK8 proliferation assays were examined to determine cell proliferation of in SU-DHL-2 and OCI-LY-10 cells after transfecting with siRNA of LDHA. A multi-way classification analysis of variance tests was performed to assess data obtained from the CCK8 assays and data are shown as mean ± SD in the bar graph for three independent experiments. *P < 0.05; **P < 0.01.