Concentrations of Inflammatory Cytokines. Box plots of plasma IL-1β (a), IL-6 (b), TNF-α (c) and INF-γ (d) in the no-DNMT3A/TET2 VAF≥2% group (n = 425) and DNMT3A/TET2 VAF≥2% group (n = 60). Box plots represented the median, interquartile (box) and 1.5 interquartile range (whiskers). P-values are for Mann-Whitney tests. *There are 3 points presenting IL-1β, 2 points presenting TNF-α, and 3 points presenting IFN-γ concentrations in the no-DNMT3A/TET2 VAF≥2% group, and 2 points presenting IL-1β concentrations in the DNMT3A/TET2 VAF≥2% group beyond the upper limit of the concentrations in the plot.