Table 2.
Univariate and multivariable COX regression models of DNMT3A/TET2 VAF≥2% group compared to No- DNMT3A/TET2 VAF≥2% group.
| Event | Unadjusted Model |
Adjusted Model 1 |
Adjusted Model 2 |
|||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| MACE | 2.319 (1.487–3.618) | <0.001 | 1.909 (1.203–3.031) | 0.006 | 1.833 (1.154-2.912) | 0.010 |
| All-cause Death | 2.442 (1.417–4.208) | 0.001 | 2.053 (1.165–3.618) | 0.013 | 1.967 (1.103-3.507) | 0.022 |
| Nonfatal MI or Stroke | 2.821 (1.463–5.440) | 0.002 | 2.551 (1.277–5.099) | 0.008 | 2.563 (1.283-5.117) | 0.008 |
| Hospitalization due to HF | 3.417 (1.405–8.308) | 0.007 | 2.295 (0.895–5.887) | 0.084 | 2.297 (0.875-6.027) | 0.091 |
Adjusted Model 1: adjusting for age, sex, hypertension, dyslipidemia, diabetes mellitus, smoking status.
Adjusted Model 2: adjusting for age, sex, hypertension, dyslipidemia, diabetes mellitus, smoking status, LVEF, ln_NT-proBNP, hs-CRP.
HF = heart failure; HR = hazard ratio; hs-CRP = hyper-sensitivity C-reactive protein; LVEF = left ventricular ejection fraction; MACE = major adverse cardic events; MI = myocardial infarction; NT-proBNP = N-terminal pro brain natriuretic peptide.