Figure 2.

Network Geometry of laboratory-confirmed influenza

Panel a: adults and elderly; Panel b: children. The thickness of the line is proportional to the precision of each direct estimate, and the width of each circle is proportional to the number of studies included in the treatment. Placebo: placebo/no vaccine; 3-IIV: trivalent inactivated intramuscular; 3-IIV HD: trivalent inactivated high dose intramuscular; 3-IIV ID: trivalent inactivated intradermal; 3-IIV MF59/AS03-adj: trivalent inactivated adjuvanted with MF59/ASO3 intramuscular: 3-RIV: trivalent recombinant intramuscular; 4-IIV: quadrivalent inactivated intramuscular; 4-RIV: quadrivalent recombinant intramuscular; 3-LAIV: trivalent live attenuated intranasal; 4-LAIV: quadrivalent live attenuated intranasal.