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. 2022 Mar 25;46:101331. doi: 10.1016/j.eclinm.2022.101331

Table 2.

Netleague laboratory-confirmed influenza: adults and elderly.

placebo 0.4 (0.34, 0.46) 0.33 (0.21, 0.55) 0.4 (0.04, 3.89) 0.37 (0.22, 0.64) 0.39 (0.23, 0.61) 0.56 (0.36, 0.83) 0.47 (0.29, 0.7) 0.56 (0.41, 0.74)
2.51 (2.18, 2.95) 3-IIV 0.83 (0.53, 1.37) 1 (0.11, 9.75) 0.94 (0.57, 1.59) 0.97 (0.59, 1.54) 1.41 (0.9, 2.15) 1.18 (0.73, 1.81) 1.41 (1.04, 1.88)
3.01 (1.82, 4.86) 1.2 (0.73, 1.88) 3-IIV HD 1.19 (0.12, 12.08) 1.13 (0.57, 2.18) 1.16 (0.57, 2.19) 1.68 (0.87, 3.07) 1.41 (0.71, 2.56) 1.68 (0.94, 2.85)
2.53 (0.26, 24.11) 1 (0.1, 9.52) 0.84 (0.08, 8.49) 3-IIV ID 0.95 (0.09, 9.45) 0.97 (0.1, 9.55) 1.41 (0.14, 13.77) 1.17 (0.12, 11.47) 1.41 (0.14, 13.68)
2.67 (1.57, 4.5) 1.06 (0.63, 1.74) 0.89 (0.46, 1.75) 1.06 (0.11, 10.86) 3-IIV MF59/AS03-adj 1.03 (0.49, 2.01) 1.49 (0.76, 2.8) 1.25 (0.62, 2.33) 1.5 (0.82, 2.63)
2.59 (1.65, 4.29) 1.03 (0.65, 1.7) 0.86 (0.46, 1.76) 1.03 (0.1, 10.51) 0.97 (0.5, 2.02) 3-RIV 1.44 (0.79, 2.74) 1.21 (0.64, 2.29) 1.45 (0.86, 2.54)
1.79 (1.21, 2.76) 0.71 (0.47, 1.11) 0.59 (0.33, 1.15) 0.71 (0.07, 7.15) 0.67 (0.36, 1.32) 0.69 (0.37, 1.27) 4-IIV 0.84 (0.56, 1.21) 1 (0.61, 1.66)
2.13 (1.42, 3.44) 0.85 (0.55, 1.38) 0.71 (0.39, 1.4) 0.85 (0.09, 8.65) 0.8 (0.43, 1.61) 0.83 (0.44, 1.55) 1.2 (0.83, 1.78) 4-RIV 1.2 (0.72, 2.05)
1.79 (1.35, 2.43) 0.71 (0.53, 0.96) 0.59 (0.35, 1.06) 0.71 (0.07, 7.02) 0.67 (0.38, 1.23) 0.69 (0.39, 1.17) 1 (0.6, 1.64) 0.84 (0.49, 1.38) 3-LAIV

The estimate is located at the intersection of the column-defining vaccine and the row-defining vaccine. Data are RRs (95% CrI). Significant results are in bold.

In the upper triangle, comparison of treatments should be read from right to left. An RR below 1 favors the medication on the bottom right vs. the medication on the top left in the diagonal. E.g., RR 0.40 (95% CrI 0.34–0.46) indicates a significant reduction in the incidence of laboratory-confirmed influenza for the trivalent inactivated vaccine (3-IIV) compared with placebo or no vaccination.

In the bottom triangle, comparison of treatments should be read from left to right. An RR below 1 favors the medication on the top left vs. the medication on the bottom right in the diagonal. E.g., RR 0.84 (95% CrI 0.08–8.49) indicates a non-significant reduction in the incidence of laboratory-confirmed influenza for the trivalent inactivated high-dose vaccine (3-IIV-HD) compared with the trivalent inactivated intradermal vaccine (3-IIV ID).

Abbreviations: Placebo: placebo or no vaccination; 3-IIV: trivalent inactivated intramuscular; 3-IIV HD: trivalent inactivated high-dose intramuscular; 3-IIV ID: trivalent inactivated intradermal; 3-IIV MF59/AS03-adj: trivalent inactivated adjuvanted with MF59/AS03 intramuscular; 3-RIV: trivalent recombinant intramuscular; 4-IIV: quadrivalent inactivated intramuscular; 4-RIV: quadrivalent recombinant intramuscular; 3-LAIV: trivalent live-attenuated intranasal.