Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 28;10(3):e004026. doi: 10.1136/jitc-2021-004026

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

High eEF2K expression positively correlates with immunotherapeutic benefits and PD-L1 level in patients with melanoma. (A) Kaplan-Meier overall survival curves in patients with melanoma with or without response to PD-1 mAb therapy. (B) Kaplan-Meier plots of the overall survival rates in PD-1 blockade-treated patients with melanoma with high (IHC overall score is between 3 and 4) or low (IHC overall score is between 0 and 2) expression of eEF2K. (C) IHC staining of 38 human melanoma specimens was performed with the eEF2K antibody. (D) Representative IHC staining images of eEF2K from respond group and non-respond group are shown, scale bar is 50 μm. (E) Schematic diagram for eEF2K as a predictor for the efficacy and prognosis of anti-PD-L1/PD-1 therapy (good prognosis means improvement or full resolution, poor prognosis means no recovery or death due to melanoma). (F, G) The positive correlation between eEF2K and PD-L1 expression in human melanoma specimens. (F) The IHC staining images, and the correlation analyses were performed (G). eEF2K, eukaryotic elongation factor 2 kinase; IHC, immunohistochemical; mAb, monoclonal antibody; PD-1, programmed cell death protein-1; PD-L1, programmed death ligand-1.