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. 2022 Mar 28;10(3):e004026. doi: 10.1136/jitc-2021-004026

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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High p-GSK3β/S9 expression is positively correlated with response to anti-PD-1 immunotherapy, eEF2K and PD-L1 levels in samples from patients with melanoma. Representative images (A) and quantitative expression (B) of immunohistochemistry staining of p-GSK3β/S9 in patients with melanoma with or without response to PD-1 mAb therapy. The positive correlation between p-GSK3β/S9 and eEF2K (C), PD-L1 (D) in human melanoma specimens. eEF2K, eukaryotic elongation factor 2 kinase; GSK3β, glycogen synthase kinase 3 beta; IHC, immunohistochemical; mAb, monoclonal antibody; PD-1, programmed cell death protein-1; PD-L1, programmed death ligand-1.