Table 8. Severity grading of abnormal vital signs.

Parameter	Grade 1 (mild)	Grade 2 (moderate)	Grade 3 (severe)
Fever	37.6°C - 38.0°C	38.1°C – 39.0°C	>39.0°C
Tachycardia (bpm) *	101 – 115	116 – 130	>130
Bradycardia (bpm) **	50 – 54	40 – 49	<40
Systolic hypertension (mmHg)	141 – 159	160 – 179	≥180
Diastolic hypertension (mmHg)	91 – 99	100 – 109	≥110
Systolic hypotension (mmHg) ***	85 – 89	80 – 84	<80

*Taken after ≥10 minutes at rest

**When resting heart rate is between 60 – 100 beats per minute. Use clinical judgement when characterising bradycardia among some healthy subject populations, for example, conditioned athletes.

***Use clinical judgement, particularly in subjects with low body weight. Consider checking lying and standing blood pressure to test for a postural drop of >20 mmHg if safe to do so. Do not record as an adverse event if hypotension is asymptomatic (e.g., absence of light-headed feeling)