Comparison 7. Global Rating ITT.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Global Rating (no change or improvement at 3 months) ITT	2		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
1.1 galantamine (18mg/d bid) vs placebo	1	162	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.44 [1.18, 5.04]
1.2 galantamine (24mg/d bid) vs placebo	1	136	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.11 [0.96, 4.62]
1.3 galantamine (24‐32 mg/d bid or tid) vs placebo	1	363	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.48 [0.92, 2.37]
1.4 galantamine (36mg/d bid) vs placebo	1	130	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.70 [1.18, 6.17]
2 Global Rating (no change or improvement at 6 months) ITT	6		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
2.1 galantamine (8mg/d bid) vs placebo	1	391	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.17 [0.77, 1.78]
2.2 galantamine (16mg/d bid) vs placebo	1	517	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.04 [1.44, 2.89]
2.3 galantamine (16‐24mg/d bid) vs placebo	1	603	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.27 [0.92, 1.76]
2.4 galantamine (16‐24mg/d Prolonged Release ) vs placebo	1	592	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.20 [0.86, 1.66]
2.5 galantamine (24mg/d bid) vs placebo	4	1570	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.90 [1.55, 2.33]
2.6 galantamine (32mg/d bid) vs placebo	2	768	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.79 [1.34, 2.38]
2.7 galantamine (32mg/d tds) vs placebo	1	525	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.28 [0.89, 1.83]