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. 2006 Jan 25;2006(1):CD001747. doi: 10.1002/14651858.CD001747.pub3

Comparison 8. ADAS‐cog (Change from baseline) ITT.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 ADAS‐cog (Change from baseline at 3 months) ITT 3   Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.1 galantamine (18mg/d bid) vs placebo 1 163 Mean Difference (IV, Fixed, 95% CI) ‐1.70 [‐3.64, 0.24]
1.2 galantamine (16‐24mg/d bid) vs placebo 1 592 Mean Difference (IV, Fixed, 95% CI) ‐2.7 [‐3.55, ‐1.85]
1.3 galantamine (16‐24mg/d Prolonged Release ) vs placebo 1 586 Mean Difference (IV, Fixed, 95% CI) 1.8 [0.94, 2.66]
1.4 galantamine (24mg/d bid) vs placebo 1 137 Mean Difference (IV, Fixed, 95% CI) ‐3.0 [‐5.23, ‐0.77]
1.5 galantamine (24‐32 mg/d bid or tid) vs placebo 1 359 Mean Difference (IV, Fixed, 95% CI) ‐1.70 [‐2.79, ‐0.61]
1.6 galantamine (36mg/d bid) vs placebo 1 133 Mean Difference (IV, Fixed, 95% CI) ‐2.3 [‐4.24, ‐0.36]
2 ADAS‐cog (Change from baseline at 6 months) ITT 6   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.1 galantamine (8mg/d bid) vs placebo 1 381 Mean Difference (IV, Fixed, 95% CI) ‐1.30 [‐2.57, ‐0.03]
2.2 galantamine (16mg/d bid ) vs placebo 1 508 Mean Difference (IV, Fixed, 95% CI) ‐3.10 [‐4.13, ‐2.07]
2.3 galantamine (16‐24mg/d bid) vs placebo 1 592 Mean Difference (IV, Fixed, 95% CI) ‐2.8 [‐3.76, ‐1.84]
2.4 galantamine (16‐24mg/d Prolonged Release ) vs placebo 1 587 Mean Difference (IV, Fixed, 95% CI) ‐2.5 [‐3.39, ‐1.61]
2.5 galantamine (24mg/d bid) vs placebo 4 1630 Mean Difference (IV, Fixed, 95% CI) ‐3.13 [‐3.70, ‐2.55]
2.6 galantamine (32mg/d bid) vs placebo 2 825 Mean Difference (IV, Fixed, 95% CI) ‐3.29 [‐4.14, ‐2.44]
2.7 galantamine (32mg/d tds) vs placebo 1 553 Mean Difference (IV, Fixed, 95% CI) ‐2.9 [‐4.01, ‐1.79]
3 ADAS‐cog (Change from baseline at 12 months in MCI) ITT 2 1903 Mean Difference (IV, Fixed, 95% CI) ‐0.11 [‐0.62, 0.40]
3.1 galantamine (16‐24mg/d bid) vs placebo in MCI 2 1903 Mean Difference (IV, Fixed, 95% CI) ‐0.11 [‐0.62, 0.40]
4 ADAS‐cog (Change from baseline at 24 months in MCI) ITT 2 1903 Mean Difference (IV, Fixed, 95% CI) ‐0.21 [‐0.78, 0.37]
4.1 galantamine (16‐24mg/d bid) vs placebo in MCI 2 1903 Mean Difference (IV, Fixed, 95% CI) ‐0.21 [‐0.78, 0.37]