1 ADAS‐cog (Change from baseline at 3 months) ITT |
3 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
1.1 galantamine (18mg/d bid) vs placebo |
1 |
163 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.70 [‐3.64, 0.24] |
1.2 galantamine (16‐24mg/d bid) vs placebo |
1 |
592 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.7 [‐3.55, ‐1.85] |
1.3 galantamine (16‐24mg/d Prolonged Release ) vs placebo |
1 |
586 |
Mean Difference (IV, Fixed, 95% CI) |
1.8 [0.94, 2.66] |
1.4 galantamine (24mg/d bid) vs placebo |
1 |
137 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.0 [‐5.23, ‐0.77] |
1.5 galantamine (24‐32 mg/d bid or tid) vs placebo |
1 |
359 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.70 [‐2.79, ‐0.61] |
1.6 galantamine (36mg/d bid) vs placebo |
1 |
133 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.3 [‐4.24, ‐0.36] |
2 ADAS‐cog (Change from baseline at 6 months) ITT |
6 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
2.1 galantamine (8mg/d bid) vs placebo |
1 |
381 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.30 [‐2.57, ‐0.03] |
2.2 galantamine (16mg/d bid ) vs placebo |
1 |
508 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.10 [‐4.13, ‐2.07] |
2.3 galantamine (16‐24mg/d bid) vs placebo |
1 |
592 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.8 [‐3.76, ‐1.84] |
2.4 galantamine (16‐24mg/d Prolonged Release ) vs placebo |
1 |
587 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.5 [‐3.39, ‐1.61] |
2.5 galantamine (24mg/d bid) vs placebo |
4 |
1630 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.13 [‐3.70, ‐2.55] |
2.6 galantamine (32mg/d bid) vs placebo |
2 |
825 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.29 [‐4.14, ‐2.44] |
2.7 galantamine (32mg/d tds) vs placebo |
1 |
553 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.9 [‐4.01, ‐1.79] |
3 ADAS‐cog (Change from baseline at 12 months in MCI) ITT |
2 |
1903 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.11 [‐0.62, 0.40] |
3.1 galantamine (16‐24mg/d bid) vs placebo in MCI |
2 |
1903 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.11 [‐0.62, 0.40] |
4 ADAS‐cog (Change from baseline at 24 months in MCI) ITT |
2 |
1903 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.21 [‐0.78, 0.37] |
4.1 galantamine (16‐24mg/d bid) vs placebo in MCI |
2 |
1903 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.21 [‐0.78, 0.37] |