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. 2022 Jan 20;18:17448069211060962. doi: 10.1177/17448069211060962

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — The establishment of breast cancer-induced bone metastasis model in rats. (a) Radiographs of tibia 21 days after Walker 256 cells inoculation. The red frame circled the damage of the proximal cortical bone. (b) 21 days after cancer cells inoculation, hematoxylin-eosin (HE) staining of the proximal cortical bones. The bone marrow spaces are full of malignant tumor cells. (c) Paw withdrawal thresholds (PWTs) were examined on baseline (1 day before surgery) and postoperative days (POD) 4, 7, 11, 14, 17, 21. Data were presented as mean ± SD (n = 8 per group). ****p < .0001 versus baseline; ^####p < .0001 versus Sham group. (d) Number of Spontaneous Flinches (NSF) was examined on baseline (1 day before surgery) and POD 4, 7, 11, 14, 17, and 21. Data were presented as mean ± SD (n = 8 per group). ****p < .0001 versus baseline; ^####p < .0001 versus Sham group.