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. 2022 Jan 20;18:17448069211060962. doi: 10.1177/17448069211060962

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — P2X7RsiRNA can reduce the polarization of microglia to M1 induced by BzATP. (a), (b), (c) Representative Western blotting bands and quantitative analysis showed the protein expression levels of CD86 and iNOS in the Control+NCsiRNA, Control+P2X7RsiRNA, LPS+BzATP+NCsiRNA, and LPS+BzATP+P2X7RsiRNA group. β-actin was used as an internal control. Data were presented as mean ± SD (n = 4 per group). **p < .01 versus Control+NCsiRNA group; ***p < .001 versus Control+NCsiRNA group; ^###p < .001 versus LPS+BzATP+NCsiRNA group. (D), (E), (F) Representative Western blotting bands and quantitative analysis showed the protein expression levels of CD163 and Arg-1 in the Control+NCsiRNA, Control+P2X7RsiRNA, LPS+BzATP+NCsiRNA, and LPS+BzATP+P2X7RsiRNA group. β-actin was used as an internal control. Data were presented as mean ± SD (n = 4 per group). ***p < .001 versus Control+NCsiRNA group; ^###p < .001 versus LPS+BzATP+NCsiRNA group. (g), (h), (i), (j) Relative mRNA expression levels of IL-18, TNF-α, IL-4, and IL-10 in the Control+NCsiRNA, Control+P2X7RsiRNA, LPS+BzATP+NCsiRNA, and LPS+BzATP+P2X7RsiRNA group. Data were presented as mean ± SD (n = 4 per group). *p < 0.05 versus Control+NCsiRNA group; ***p < 0.001 versus Control+NCsiRNA group; ^#p < 0.05 versus LPS+BzATP+NCsiRNA group; ^##p < 0.01 versus LPS+BzATP+NCsiRNA group; ^###p < 0.001 versus LPS+BzATP+NCsiRNA group.