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. 2021 Jul 14;28(4):522–531. doi: 10.1177/13524585211028831

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© The Author(s), 2021

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Retinal architecture, vasculature, and surrogate markers of disease activity in neuromyelitis optica spectrum disorders. (a) Association of the Expanded Disability Status Scale (EDSS) and the foveal avascular zone (FAZ) areas during neuromyelitis optica spectrum disorders (NMOSD) (n = 15); β regression estimate and 95% confidence interval (CI); symbols depict single patients; multiple linear regression model corrected for age and sex. (b) Serum levels of neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) in healthy individuals (HC, n = 21), patients with relapsing-remitting MS (MS, n = 21) and NMOSD (n = 15); mean ± standard deviation; symbols depict single patients; Kruskal–Wallis test (sNfL), one-way ANOVA (GFAP). (c–e) Association of sGFAP levels and foveal thickness (FT) (c), vessel densities of the superficial vascular complex (SVC) (d), and the foveal avascular zone (FAZ) areas (e) in eyes without former optic neuritis in patients with NMOSD (n = 15); β regression estimates and 95% CI; symbols depict single patients; multiple linear regression models corrected for age, sex, and EDSS.