Table 7.
Unadjusted outcomes, stratified by IV-VitC
| Outcome | IV-VitC | Control | OR (95% CI) | P value |
|---|---|---|---|---|
| ICU admission | (n = 25) | (n = 75) | ||
| No | 3 (12.0%) | 12 (16.0%) | 1.4 (0.4, 5.4) | 0.6290 |
| Yes | 22 (88.0%) | 63 (84.0%) | ||
| Time to ICU (days) | (n = 22) | (n = 63) | – (–, –) | 0.5240 |
| Mean (Standard Deviation) | 4.5 (4.2) | 3.9 (4.4) | ||
| ICU LOS (days) | (n = 22) | (n = 60) | – (–, –) | 0.0535 |
| Mean (Standard Deviation) | 16.9 (15.7) | 9.2 (9.0) | ||
| Mechanical ventilation | (n = 25) | (n = 75) | ||
| No | 7 (28.0%) | 21 (28.0%) | 1.0 (0.4, 2.7) | 0.9999 |
| Yes | 18 (72.0%) | 54 (72.0%) | ||
| Time to ventilation (days) | (n = 18) | (n = 54) | ||
| Mean (standard deviation) | 6.9 (5.0) | 4.7 (4.6) | – (–, –) | 0.0922 |
| Time on ventilator (days) | (n = 11) | (n = 49) | ||
| Mean (standard deviation) | 15.6 (10.6) | 7.9 (6.9) | – (–, –) | 0.0097 |
| Transfer out on ventilator | (n = 23) | (n = 52) | ||
| No | 18 (78.3%) | 43 (82.7%) | 1.3 (0.4, 4.5) | 0.6503 |
| Yes | 5 (21.7%) | 9 (17.3%) | ||
| Reintubation | (n = 21) | (n = 48) | ||
| No | 18 (85.7%) | 40 (83.3%) | 0.8 (0.2, 3.5) | 0.8758 |
| Yes | 3 (14.3%) | 8 (16.7%) | ||
| Time to reintubation (days) | (n = 4) | (n = 9) | ||
| Mean (standard deviation) | 6.5 (6.5) | 5.7 (5.4) | – (–, –) | 0.8132 |
| Pressors requirement | (n = 25) | (n = 75) | ||
| No | 10 (40.0%) | 27 (36.0%) | 0.8 (0.3, 2.1) | 0.7199 |
| Yes | 15 (60.0%) | 48 (64.0%) | ||
| Development of AKI | ||||
| No | 11 (44.0%) | 18 (24.0%) | 0.4 (0.2, 1.0) | 0.0602 |
| Yes | 14 (56.0%) | 57 (76.0%) | ||
| AKI needing RRT | ||||
| No | 21 (84.0%) | 57 (76.0%) | 0.6 (0.2, 2.0) | 0.4064 |
| Yes | 4 (16.0%) | 18 (24.0%) | ||
| Confirmed DVT/PE | (n = 24) | (n = 75) | ||
| No | 22 (91.7%) | 69 (92.0%) | 1.1 (0.2, 5.6) | 0.9584 |
| Yes | 2 (8.3%) | 6 (8.0%) | ||
| ICU readmission | (n = 24) | (n = 59) | ||
| No | 19 (79.2%) | 55 (93.2%) | 3.6 (0.9, 14.9) | 0.0747 |
| Yes | 5 (20.8%) | 4 (6.8%) | ||
| Cardiac arrest | (n = 24) | (n = 75) | ||
| No | 22 (91.7%) | 67 (89.3%) | 0.8 (0.2, 3.9) | 0.7420 |
| Yes | 2 (8.3%) | 8 (10.7%) | ||
| Time to cardiac arrest (days) | (n = 2) | (n = 8) | ||
| Mean (standard deviation) | 21.5 (7.8) | 12.6 (8.5) | – (–, –) | 0.1497 |
| Death | (n = 25) | (n = 75) | ||
| No | 15 (60.0%) | 38 (50.7%) | 0.7 (0.3, 1.7) | 0.4193 |
| Yes | 10 (40.0%) | 37 (49.3%) | ||
| Time to death (days) | (n = 10) | (n = 37) | ||
| Mean (standard deviation) | 22.9 (11.2) | 13.7 (10.7) | – (–, –) | 0.0139 |
| Overall LOS (Days) | (n = 25) | (n = 75) | ||
| Mean (standard deviation) | 26.7 (15.0) | 18.7 (11.9) | – (–, –) | 0.0140 |
ICU intensive care unit LOS length of stay AKI acute kidney injury RRT renal replacement therapy DVT deep venous thrombosis PE pulmonary embolism