Table 3.

Results of the meta-regression analysis of CO-RADS for the detection of COVID-19

Cutoff	Covariates	Category	Studies (n)	Meta-analytic summary estimates
				Sensitivity (95% CI)	p	Specificity (95% CI)	p
3	Publication year	2021	14	0.89 (0.84–0.93)	0.00	0.69 (0.61–0.78)	0.55
		2020	6	0.91 (0.85–0.97)		0.63 (0.49–0.77)
	Study design	R	16	0.89 (0.84–0.93)	0.03	0.66 (0.58–0.75)	0.17
		P	3	0.92 (0.84–0.99)		0.73 (0.56–0.90)
	Enrollment	C	13	0.87 (0.82–0.92)	0.00	0.71 (0.63–0.80)	0.80
		NA	7	0.93 (0.88–0.97)		0.60 (0.47–0.73)
	Centers (n)	< 2	14	0.89 (0.84–0.94)	0.00	0.68 (0.59–0.77)	0.56
		≥.	5	0.91 (0.85–0.97)		0.63 (0.47–0.79)
	Readers (n)	< 3	3	0.94 (0.86–1.00)	0.88	0.70 (0.49–0.91)	0.78
		≥ 3	11	0.87 (0.80–0.94)		0.66 (0.54–0.78)
	Setting	ED	9	0.93 (0.90–0.97)	0.02	0.62 (0.50–0.73)	0.02
		NA	11	0.85 (0.79–0.91)		0.72 (0.63–0.81)
4	Publication year	2021	16	0.84 (0.80–0.88)	0.00	0.84 (0.78–0.90)	0.02
		2020	7	0.82 (0.75–0.88)		0.84 (0.74–0.93)
	Study design	R	18	0.83 (0.79–0.87)	0.00	0.82 (0.76–0.88)	0.02
		P	3	0.86 (0.78–0.94)		0.89 (0.80–0.99)
	Enrollment	C	14	0.81 (0.77–0.86)	0.00	0.85 (0.79–0.91)	0.05
		NA	9	0.87 (0.82–0.92)		0.81 (0.72–0.90)
	Centers (n)	< 2	15	0.82 (0.78–0.87)	0.00	0.84 (0.78–0.91)	0.13
		≥.	6	0.85 (0.80–0.91)		0.81 (0.69–0.92)
	Readers (n)	< 3	4	0.84 (0.75–0.93)	0.03	0.82 (0.66–0.97)	0.22
		≥ 3	12	0.81 (0.76–0.87)		0.84 (0.76–0.92)
	Setting	ED	10	0.87 (0.84–0.91)	0.00	0.82 (0.74–0.90)	0.00
		NA	13	0.79 (0.74–0.84)		0.85 (0.78–0.91)

Abbreviations: ED, emergency department; NA, not available; CI, confidence interval