Table 4.

Results of subgroup analyses of CO-RADS for the detection of COVID-19

Cutoff	Covariates	Subgroup	Studies (n)	Meta-analysis summary estimates
				Sensitivity (95% CI)	p	Specificity (95% CI)	p
3	Age#	< 60	3	0.96 (0.92–1.00)	0.81	0.57 (0.36–0.79)	0.10
		≥ .1	14	0.87 (0.81–0.92)		0.72 (0.64–0.80)
	Sex*	< 50%	3	0.90 (0.80–1.00)	0.16	0.77 (0.63–0.92)	0.87
		≥ 50%	17	0.89 (0.85–0.94)		0.66 (0.58–0.74)
	Symptoms	S	17	0.90 (0.86–0.94)	0.26	0.64 (0.56–0.72)	0.00
		B	3	0.87 (0.75–0.99)		0.83 (0.72–0.93)
4	Age#	< 60	4	0.88 (0.82–0.94)	0.02	0.77 (0.62–0.92)	0.01
		≥ .0	14	0.80 (0.75–0.85)		0.87 (0.82–0.92)
	Sex*	< 50%	3	0.88 (0.80–0.96)	0.07	0.92 (0.86–0.99)	0.70
		≥ .70	20	0.83 (0.79–0.86)		0.82 (0.76–0.87)
	Symptoms	S	19	0.83 (0.79–0.87)	0.01	0.81 (0.75–0.87)	0.00
		B	4	0.83 (0.74–0.92)		0.92 (0.86–0.98)

Abbreviations: S, symptomatic; B, both symptomatic and asymptomatic; CI, confidence interval

^#Age: median age or average age

^*Sex: proportion of male subjects, including two groups: < 50% male subjects and ≥ 50% male subjects