TABLE 2.

In vitro activities of different antibiotics against Lactobacillus spp.^a

Microorganisms (no. of isolates)	Antimicrobial agent	MIC (μg/ml)b
		Range	50%	90%
L. plantarum (28)	Erythromycin A	0.03–0.125	0.06	0.125
	Clarithromycin	0.0007–0.06	0.007	0.06
	Roxithromycin	0.03–0.5	0.06	0.25
	Azithromycin	0.0035–0.125	0.06	0.125
	HMR3647	≤0.0007–0.015	0.007	0.015
	Spiramycin	0.25–1	0.25	0.5
	Pristinamycin I	2–16	4	16
	Vancomycin	1,024–≥4,096	≥4,096	≥4,096
	Teicoplanin	1,024–≥4,096	≥4,096	≥4,096
	Penicillin	2–≥128	8	≥128
	Ciprofloxacin	4–64	16	32
	Levofloxacin	0.125–16	4	8
L. paracasei (17)	Erythromycin A	0.03–256	0.06	0.125
	Clarithromycin	0.0035–128	0.03	0.03
	Roxithromycin	0.015–128	0.125	0.125
	Azithromycin	0.03–128	0.06	0.06
	HMR3647	≤0.0007–0.5	0.007	0.015
	Spiramycin	0.25–16	0.5	0.5
	Pristinamycin I	0.25–2	0.5	2
	Vancomycin	4–≥4,096	1,024	≥4,096
	Teicoplanin	4–≥4,096	512	1,024
	Penicillin	0.25–2	0.5	1
	Ciprofloxacin	0.5–2	1	2
	Levofloxacin	0.5–2	2	2
L. brevis (8)	Erythromycin A	0.03–0.125	—c	—
	Clarithromycin	≤0.0007–0.06	—	—
	Roxithromycin	0.007–0.25	—	—
	Azithromycin	0.0035–0.125	—	—
	HMR3647	≤0.0007–0.015	—	—
	Spiramycin	0.125–0.5	—	—
	Pristinamycin I	1–16	—	—
	Vancomycin	128–≥4,096	—	—
	Teicoplanin	8–≥4,096	—	—
	Penicillin	0.25–128	—	—
	Ciprofloxacin	2–32	—	—
	Levofloxacin	2–8	—	—
Lactobacillus spp. (7)	Erythromycin A	0.03–0.06	—	—
	Clarithromycin	0.015–0.06	—	—
	Roxithromycin	0.06–0.125	—	—
	Azithromycin	0.03–0.25	—	—
	HMR3647	≤0.0007–0.007	—	—
	Spiramycin	0.06–0.5	—	—
	Pristinamycin I	0.25–8	—	—
	Vancomycin	128–≥4,096	—	—
	Teicoplanin	2–512	—	—
	Penicillin	0.25–≥128	—	—
	Ciprofloxacin	0.5–4	—	—
	Levofloxacin	0.25–4	—	—

^aAgar dilution in BHIA and 5% CO₂. 

^b50% and 90%, MIC₅₀ and MIC₉₀, respectively. 

^c—, too few isolates for MIC determinations.