Fig. 1.

Gibbs energies of binding and binding phenomenological coefficients, L_B, of SARS-CoV-2 strains and their dates of first isolation. The blue triangles () represent Gibbs energies of binding, while the orange circles () represent L_B coefficients. All binding phenomenological coefficient values were multiplied by 10¹⁸ to make the presentation simpler. Both Gibbs energies of binding and binding phenomenological coefficients are at 37 °C. Δ_BG⁰(37°C) represents standard Gibbs energy of binding at 37 °C, with unit concentrations and at a pressure of 10⁵ Pa (IUPAC, 1997). Δ_BG⁰(37°C) is the standard Gibbs energy change of reaction (1). Δ_BG⁰(37°C) is related to the binding equilibrium constant at 37 °C, through the equation Δ_BG⁰(37°C) = - R_g ⋅ (310.15 K) ⋅ ln[K_B(37 °C)]. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)