Fig. 2.

Gibbs energies of binding and binding phenomenological coefficients, L_B, of SARS-CoV-2 strains and their dates of first isolation. The blue triangles () represent Gibbs energies of binding, while the orange circles () represent binding phenomenological coefficients. All binding phenomenological coefficient values were multiplied by 10¹⁸ to make the presentation simpler. Both Gibbs energies of binding and binding phenomenological coefficients are at 25 °C. Δ_BG⁰(25°C) represents standard Gibbs energy of binding at 37 °C, with unit concentrations and at a pressure of 10⁵ Pa (IUPAC, 1997). Δ_BG⁰(25°C) is the standard Gibbs energy change of reaction (1). Δ_BG⁰(25°C) is related to the binding equilibrium constant at 37 °C, through the equation Δ_BG⁰(25°C) = - R_g ⋅ (298.15 K) ⋅ ln[K_B(25 °C)]. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)