Table 4.
Binding rates, rB, calculated at 25 °C and 37 °C. An assumption was made that the inoculum size is the same for all strains. The rates were calculated using equation (12), with the L and ΔBG⁰ values from Table 1.
| Mutations | Reference | T (°C) | rB ∙ 1019 (M/s) |
|---|---|---|---|
| At 25°C | |||
| Wild type (Hu-1) | Laffeber et al., 2021 | 25 | 22.95 |
| N501Y | Laffeber et al., 2021 | 25 | 4.55 |
| E484K | Laffeber et al., 2021 | 25 | 35.23 |
| K417 N | Laffeber et al., 2021 | 25 | 72.21 |
| E484K/N501Y | Laffeber et al., 2021 | 25 | 5.26 |
| K417 N/E484K/N501Y | Laffeber et al., 2021 | 25 | 14.02 |
| Wild type (Hu-1) | Augusto et al. (2021) | 25 | 9.46 |
| E484K | Augusto et al. (2021) | 25 | 9.38 |
| L452R/E484Q | Augusto et al. (2021) | 25 | 10.66 |
| N440K | Augusto et al. (2021) | 25 | 9.48 |
| At 37°C | |||
| Wild type (Hu-1) | Barton et al. (2021) | 37 | 162.99 |
| K417 N | Barton et al. (2021) | 37 | 443.48 |
| K417T | Barton et al. (2021) | 37 | 331.77 |
| S477 N | Barton et al. (2021) | 37 | 102.14 |
| E484K | Barton et al. (2021) | 37 | 236.80 |
| N501Y (Alpha) | Barton et al. (2021) | 37 | 29.01 |
| K417 N/E484K | Barton et al. (2021) | 37 | 678.65 |
| K417T/E484K | Barton et al. (2021) | 37 | 443.72 |
| E484K/N501Y (UK2) | Barton et al. (2021) | 37 | 29.19 |
| K417 N/E484K/N501Y | Barton et al. (2021) | 37 | 79.17 |
| K417T/E484K/N501Y (Gamma) | Barton et al. (2021) | 37 | 60.49 |