Table 3.

Adjusted^a associations of FLS and FH Yes/No indicators for depression and/or anxiety with clinical and psychosocial vulnerabilities (N = 1425)

	Measures of familial risk for depression and/or anxiety
Vulnerabilities	FLS			FH (Yes/No)
	b	[95% CIb]	β	b	(95% CIb)	β
Clinical
Severity of depressive symptoms	0.80	[0.19 to 1.42]	0.07*	0.35	[−0.72 to 1.43]	0.02
Severity of anxiety symptoms	0.54	[0.10 to 0.98]	0.07*	0.37	[−0.40 to 1.13]	0.02
Disease burdenb	3.30	[1.30 to 5.30]	0.10**	4.96	[1.47 to 8.45]	0.07**
Age of onset of depression/anxiety	−1.31	[−2.09 to −0.52]	−0.09**	−2.56	[−3.93 to −1.19]	−0.09***
Psychosocial
Neuroticism	0.52	[0.08 to 0.97]	0.07*	0.71	[−0.07 to 1.48]	0.05
Introversion	0.24	[−0.15 to 0.63]	0.03	0.26	[−0.42 to 0.94]	0.02
External locus of control	0.11	[−0.11 to 0.34]	0.03	0.28	[−0.11 to 0.67]	0.04
Hopelessness	0.19	[−0.02 to 0.40]	0.05	0.31	[−0.05 to 0.68]	0.04
Rumination	0.49	[0.25 to 0.73]	0.12***	0.74	[0.32 to 1.17]	0.09***
Anxiety sensitivity	0.26	[−0.21 to 0.73]	0.03	0.29	[−0.53 to 1.10]	0.02
Childhood trauma	0.29	[0.17 to 0.42]	0.13***	0.40	[0.18 to 0.62]	0.09***
Recentc negative life events	0.06	[−0.03 to 0.15]	0.04	0.16	[0.003 to 0.31]	0.05

b, unstandardized regression coefficient; 95% CI_b, 95% confidence interval of b; β, standardized regression coefficient.

Note. Sample sizes vary slightly due to marginally missing data. Significance is indicated with raw p values using the Benjamini–Hochberg procedure (Benjamini & Hochberg, 1995) with a false discovery rate of 5% to correct for multiple testing.

^aAll linear regression models were adjusted for age, gender, and years of education.

^bMeasured as mean % of time with depression/anxiety symptoms in past 14 years.

^cPast 3-year.

***p < 0.001; **p < 0.01; *p < 0.05.