Skip to main content
. 2022 Mar 14;11(3):e32352. doi: 10.2196/32352

Table 2.

Single nucleotide polymorphisms measured in the Dortmund Vital Study (N=528) with the number of observed and expected common homozygotes, heterozygotes, and rare homozygotes in parentheses computed using the Hardy-Weinberg equilibrium calculated on the internet [46]a.

Genotype rs (reference SNPb cluster ID) Allele observed (n) Allele expected (n) χ2 (df)
Apoc-E2, E3, E4




7412 0=CC (443), 1=CT (83), 2=TT (3) 0=CC (444), 1=CT (81), 2=TT (4) 0.14 (2)

429358 0=CC (10), 1=CT (127), 2=TT (389) 0=CC (10), 1=CT (126), 2=TT (389) 0.01 (2)
BDNFd Val66Met 6265 0=GG (365), 1=GA (148), 2=AA (15) 0=GG (365), 1=GA (148), 2=AA (15) 0.00 (2)
COMT-1e 4633 0=CC (128), 1=CT (256), 2=TT (144) 0=CC (124), 1=CT (263), 2=TT (140) 0.45 (2)
COMT-2 Val158Met 4680 0=AA (144), 1=AG (256), 2=GG (128) 0=AA (140), 1=AG (263), 2=GG (124) 0.45 (2)
DRD2f 6277 0=CC (112), 1=CT (275), 2=TT (141) 0=CC (118), 1=CT (263), 2=TT (146) 1.06 (2)
DRD1g-48A/G 4532 0=CC (39), 1=CT (129), 2=TT (93) 0=CC (41), 1=CT (124), 2=TT (95) 0.27 (2)
CHRNA6h-1 1072003 0=CC (346), 1=CG (161), 2=GG (21) 0=CC (344), 1=CG (163), 2=GG (19) 0.17 (2)
CHRNA6-3 2304297 0=AA (32), 1=AG (200), 2=GG (296) 0=AA (33), 1=AG (198), 2=GG (297) 0.05 (2)
CHRNB3i-1 13280604 0=AA (311), 1=AG (192), 2=GG (25) 0=AA (314), 1=AG (186), 2=GG (28) 0.40 (2)
CHRNB3-2 4950 0=AA (311), 1=AG (191), 2=GG (26) 0=AA (313), 1=AG (187), 2=GG (28) 0.23 (2)
GPCPD1j (EDI3) 6116869 0=GG (198), 1=GT (249), 2=TT (79) 0=GG (198), 1=GT (249), 2=TT (79) 0.00 (2)
GRIN2Ak 1969060 0=CC (19), 1=CT (165), 2=TT (342) 0=CC (19), 1=CT (164), 2=TT (343) 0.02 (2)
GRIN2A 8057394 0=GG (285), 1=GC (207), 2=CC (36) 0=GG (286), 1=GC (205), 2=CC (37) 0.03 (2)
GRIN2Bl 890 0=GG (126), 1=TG (254), 2=TT (148) 0=GG (121), 1=TG (263), 2=TT (143) 0.69 (2)
ILm-1beta 16944 0=GG (235), 1=GA (221), 2=AA (70) 0=GG (227), 1=GA (237), 2=AA (62) 2.43 (2)
IL-6 1800795 0=CC (85), 1=CG (265), 2=GG (176) 0=CC (90), 1=CG (255), 2=GG (181) 0.78 (2)
IL-12A 568408 0=AA (9), 1=AG (141), 2=GG (178) 0=AA (19), 1=AG (120), 2=GG (188) 9.53 (2)
TNF-alphan 1800629 0=AA (15), 1=AG (141), 2=GG (372) 0=AA (14), 1=AG (143), 2=GG (370) 0.13 (2)

aThe chi-square test indicates the conformity between the expected and observed distribution. Significant deviances from the HWE are italicized.

bSNP: single nucleotide polymorphism.

cAPO: apolipoprotein.

dBDNF: brain-derived neurotrophic factor.

eCOMT: catechol-O-methyltransferase.

fDRD2: dopamine receptor D2.

gDRD1: dopamine receptor D1.

hCHRNA6: cholinergic receptor nicotinic alpha 6.

iCHRNB3: cholinergic receptor nicotinic beta 3.

jGPCPD1: glycerophosphocholine phosphodiesterase.

kGRIN2A: glutamate ionotropic receptor NMDA type subunit 2A.

lGRIN2B: glutamate ionotropic receptor NMDA type subunit 2B.

mIL: interleukin.

nTNF-alpha: tumor necrosis factor-alpha.