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. 2022 Mar 14;10(3):e33182. doi: 10.2196/33182

Table 1.

Characteristics of the included studies (N=15).

Type of cancer and study Country Study type Treatment Sample size Algorithms Input features (total number of features) Outcome




Training Testing Validating


All cancer

Sena et al [38] Brazil 1b All 543 N/Aa N/A DTb, ANNc, and NBd Comorbidity and PROe for physical and mental status assessments (9) 180-day death

Parikh et al [39] United States 2a All 18,567 7958 N/A GBTf and RFg Demographic, clinicopathologic, laboratory, comorbidity, and electrocardiogram data (599) 180-day death

Manz et al [37] United States 4 All N/A N/A 24,582 GBT Same as Parikh et al [39] 180-day death

Bertsimas et al [50] United States 2a All 14,427 9556 N/A DT, regularized LRh, and GBT Demographic, clinicopathologic, gene mutations, prior treatment, comorbidity, use of health care resources, vital signs, and laboratory data (401) 180-day death

Elfiky et al [43] United States 2b All 17,832 9114 N/A GBT Demographic, clinicopathologic, prescription, comorbidity, laboratory, vital sign, and use of health care resources data and physician notes (5390) 180-day death
Non–small cell lung cancer

Hanai et al [44] Japan 2b Curative resection 125 48 N/A ANN Demographic, clinicopathologic, and tumor entity data (17) 1-year death
Gastric cancer

Nilsaz-Dezfouli et al [45] Iran 1b Surgery 452 N/A N/A ANN Demographic, clinicopathologic, tumor entity, and prior treatment (20) 1-year death
Colon and rectum cancer

Arostegui et al [46] Spain 2a Curative or palliative surgery 981 964 N/A DT and regularized LR Demographic, clinicopathologic, tumor entity, comorbidity, ASAi prior treatment, laboratory, operational data, postoperational complication, and use of health care resources data (32) 1-year death
Stomach cancer

Biglarian et al [47] Iran 2a Surgery 300 136 N/A ANN Demographic, clinicopathologic, and symptom data (NRj) 1-year death
Bladder cancer

Klén et al [48] Turkey 2a Radical cystectomy 733 366 N/A Regularized LR Demographic, clinicopathologic, ASA, comorbidity, laboratory, prior treatment, tomography, and operational data (NR) 90-day death
Hepatocellular carcinoma

Chiu et al [49] Taiwan 2a Liver resection 347 87 N/A ANN Demographic, clinicopathologic, tumor entity, comorbidity, ASA, laboratory, operational, and postoperational data (21) 1-year death

Zhang et al [40] China 2a Liver transplant 230 60 N/A ANN Donor demographic data and recipient laboratory, clinicopathologic, and image data (14) 1-year death
Spinal metastatic

Karhade et al [41] United States 2a Surgery 1432 358 N/A ANN, SVMk, DT, and BPMl Demographic, clinicopathologic, tumor entity, ASA, laboratory, and operational data (23) 30-day death

Karhade et al [42] United States 2a Surgery 587 145 N/A SGBm, RF, ANN, SVM, and regularized LR Demographic, clinicopathologic, tumor entity, laboratory, operational, ECOGn, ASIAo, and prior treatment data (29) 90-day death

Karhade et al [36] United States 4 Curative surgery N/A N/A 176 SGB ECOG, demographic, clinicopathologic, tumor entity, laboratory, prior treatment, and ASIA data (23) 1-year death

aN/A: not applicable.

bDT: decision tree.

cANN: artificial neural network.

dNB: naive Bayes.

ePRO: patient-reported outcome.

fGBT: gradient-boosted tree.

gRF: random forest.

hLR: logistic regression.

iASA: American Sociological Association.

jNR: not reported.

kSVM: support vector machine.

lBPM: Bayes point machine.

mSGB: stochastic gradient boosting.

nECOG: Eastern Cooperative Oncology Group.

oASIA: American Spinal Injury Association.