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. 2022 Mar 14;10(3):e33182. doi: 10.2196/33182

Table 3.

The Model development processes and evaluations used in the included studies.

Type and study Data preprocessing Model optimization Interpretation

Numeric variables Categorical
variables
Missing data Feature
selection
Hyperparameter
value selection
Generalizability
consideration

Type 1b

Sena et al [38] Normalization N/Aa NRb None Software default 10-fold CVc VId

Nilsaz-Dezfouli et al [45] NR NR NR VI Grid search 5×5-fold CV VI
Type 2a

Parikh et al [39] NR NR Constant value imputation Zero variance and between-variable correlation Grid search 5-fold CV VI and coefficient

Klén et al [48] NR NR Complete cases only LASSOe LRf NR NR VI

Karhade et al [42] NR NR missForest multiple imputation RFg NR 3×10-fold CV VI, PDPh, and LIMEi

Karhade et al [41] NR NR Multiple imputation Recursive feature selection NR 10-fold CV NR

Arostegui et al [46] Discretization One-hot encoding Constant value imputation RF variable importance Software default Bootstrapping VI and decision tree rules

Bertsimas et al [50] NR NR Optimal impute algorithm None NR NR VI and decision tree rules

Chiu et al [49] NR NR Complete cases only Univariate Cox proportional hazard model NR NR VI

Zhang et al [40] Normalization One-hot encoding NR Forward stepwise selection algorithm NR 10-fold CV VI

Biglarian et al [47] NR NR NR None NR NR NR
Type 2b

Elfiky et al [43] NR NR Probabilistic imputation None Grid search 4-fold CV VI

Hanai et al [44] Standardization NR NR Between-variable correlation and PIMj NR 5-fold CV VI
Type 4

Manz et al [37] NR NR Constant value imputation N/A N/A N/A VI and coefficient

Karhade et al [36] NR NR missForest multiple imputation N/A N/A N/A NR

aN/A: not applicable.

bNR: not reported.

cCV: cross-validation.

dVI: variable importance.

eLASSO: least absolute shrinkage and selection operator.

fLR: logistic regression.

gRF: random forest.

hPDP: partial dependence plot.

iLIME: local interpretable model-agnostic explanation.

jPIM: parameter-increasing method.